Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Lidocaine Hydrochloride
1. Basic Information
Name: Lidocaine hydrochloride
Alias: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride, Lignocaine HCl
CAS No.: 73-78-9
Molecular Formula: C14H23ClN2O
Molecular Weight: 270.80
Category: Amide local anesthetic API, antiarrhythmic pharmaceutical raw material, medical injection intermediate, analytical reference standard
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slightly bitter taste with numb sensation on tongue contact
- Solubility: Freely soluble in water, methanol, ethanol; slightly soluble in chloroform; practically insoluble in ether, aliphatic hydrocarbons
- Melting Point: 75–79 °C (hydrate); anhydrous form 134–136 °C
- Predicted Density: 1.06 g/cm3
- Hygroscopy: Slightly hygroscopic, easy to absorb moisture in high humidity
- Aqueous property: Weakly acidic aqueous solution; stable under neutral and weak acid conditions; hydrolyzed under strong alkaline heating
Chemical Properties
- Molecular structure: Amide-type aromatic amine hydrochloride, containing diethylamino side chain and 2,6-dimethylphenyl amide core structure
- Pharmacological core characteristics: Amide bond structure ensures longer metabolic half-life compared with ester anesthetics (procaine); blocks sodium ion channels to achieve nerve conduction anesthesia
- Hydrolysis performance: Amide bond stable under room temperature neutral environment; strong alkali heating breaks amide to generate 2,6-xylidine and diethylaminoacetic acid salt
- Photostability: Moderate light resistance; long-term strong light exposure slightly darkens aqueous solution
- Thermal stability: Stable below 100 °C; high-temperature sterilization (121℃) short time heating has no obvious degradation; long-time high temperature accelerates decomposition
- Compatibility: Compatible with common injection auxiliary materials (glucose, sodium chloride); incompatible with strong alkali, heavy metal ions and strong oxidants
3. Main Application Fields
1. Medical Local Anesthetic API (Core Application)
Main raw material for injection, external ointment, spray local anesthetics; widely used in surgical surface anesthesia, infiltration anesthesia, nerve block anesthesia, epidural anesthesia
2. Antiarrhythmic Cardiovascular Drug Raw Material
First-line drug for emergency treatment of ventricular arrhythmia, used for acute myocardial infarction induced ventricular premature beat, ventricular tachycardia
3. Medical Compound Preparation Intermediate
Compound pain-relief, anti-itch external preparations, catheter lubricant additive
4. Pharmacopoeia Reference Standard
HPLC detection reference substance for lidocaine residual and related substance inspection in pharmaceutical preparations
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 73-78-9 |
| Molecular Formula | C14H23ClN2O |
| Appearance | Uniform white crystalline powder without discoloration or agglomeration |
| HPLC Purity | Pharmacopoeia API Grade ≥99.0%, Reference Standard Grade ≥99.8% |
| Melting Point | Anhydrous 134–136 °C |
| Water Content (KF) | ≤0.50% |
| Related Substances Single Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Endotoxin | ≤0.1 EU/mg (Injection Grade) |
| Packaging | Light-proof aluminum foil vacuum bag; bulk 25kg food-grade PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 °C, light shielding, isolated from alkaline and oxidizing substances |
| Transportation Requirement | Stable medical crystalline powder, general pharmaceutical chemical transportation standard, avoid damp and sunlight |
| Shelf Life | 36 months under intact sealed packaging |
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