Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
4-Amino-3,5-dichloroacetophenone
1. Basic Information
Name: 4-Amino-3,5-dichloroacetophenone
Alias: 1-(4-Amino-3,5-dichlorophenyl)ethanone
CAS No.: 37148-48-4
Molecular Formula: C8H7Cl2NO
Molecular Weight: 204.05
Category: Veterinary drug intermediate, bactericide intermediate, organic synthesis raw material, diazotization reaction substrate
2. Physical and Chemical Properties
Physical Properties
- Appearance: Off-white to pale yellow crystalline powder
- Odor: Slight aromatic ketone odor
- Solubility: Soluble in ethyl acetate, DMF, chloroform, hot ethanol; slightly soluble in methanol; insoluble in cold water, petroleum ether
- Melting Point: 148–152 °C
- Density (20 °C): 1.41 g/cm3
- Hygroscopy: Non-hygroscopic under sealed storage
- Aqueous property: Weakly alkaline aromatic amine, stable in neutral cold water
Chemical Properties
- Molecular structure: Benzene ring substituted with acetyl at C1, two Cl at C3/C5, primary -NH2 at C4; active functional groups: amino, carbonyl, aryl chloride
- Amino reactivity: Can undergo diazotization, acylation, condensation, coupling reaction to construct heterocyclic drug skeletons
- Carbonyl reactivity: Support aldol condensation, reduction, imination derivatization
- Photostability: Light sensitive; long-term light exposure produces dechlorination impurities and darkens
- Thermal stability: Stable below 140 °C; decomposes above melting point to release irritating hydrogen chloride fumes
- Compatibility: Compatible with polar aprotic solvents; incompatible with strong oxidants, concentrated strong acid
3. Main Application Fields
1. Pharmaceutical & Veterinary Intermediate (Core Application)
Key raw material for synthetic antibacterial, anti-coccidiosis veterinary APIs; prepare chlorinated aromatic heterocyclic compounds via diazotization cyclization
2. Pesticide Fungicide Intermediate
Synthesize halogenated bactericides with high activity against crop fungi
3. Organic Synthesis Lab Reagent
Standard substrate for diazotization, Suzuki coupling and aromatic ring functionalization research
4. Azo Dye Precursor
Raw material for high light fastness textile azo dyes
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 37148-48-4 |
| Molecular Formula | C8H7Cl2NO |
| Appearance | Uniform pale yellow crystal without dark impurities |
| HPLC Purity | Pharma Grade ≥99.0%, Industrial Grade ≥98.5% |
| Melting Point | 148–152 °C |
| Water Content (KF) | ≤0.20% |
| Single Unknown Impurity | ≤0.10% |
| Total Impurities | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Light-proof aluminum foil vacuum bag; bulk 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 °C, light shielding, separate from acid and oxidants |
| Transportation Requirement | Common industrial chemical solid, avoid damp and direct sunlight |
| Shelf Life | 24 months under nitrogen sealed packaging |
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