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1-[(4-Amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridinium chloride
1. Basic Product Information
Product Name: 1-[(4-Amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridinium chloride
CAS Number: 137-88-2
Molecular Formula: C14H19ClN4
Molecular Weight: 278.78
Synonyms: Thiamine chloride analog, Pyrithiamine chloride, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride
Product Category: Biochemical research reagent, vitamin antagonist, pharmaceutical intermediate, enzyme inhibitor raw material
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water, methanol; soluble in ethanol; slightly soluble in acetone; insoluble in chloroform, alkanes
- Melting Point: 248–252 °C (decomposes)
- Density (20 °C): 1.18 g/cm3
- Hygroscopicity: Moderately hygroscopic, absorbs moisture in humid air
- Aqueous Stability: Stable under weak acidic aqueous conditions; decomposes slowly under alkaline and high temperature conditions
Chemical Characteristics
- Molecular Structure: Cationic heterocyclic salt composed of aminopyrimidine side chain and methylpyridinium, paired with chloride anion
- Core Biological Function: Thiamine (vitamin B1) competitive antagonist, inhibits thiamine-dependent enzyme activity in cells
- Hydrolysis Tendency: Pyridinium methyl linkage is susceptible to cleavage under strong alkaline heating
- Photostability: Light-sensitive; long-term light exposure causes discoloration and reduced biological activity
- Thermal Stability: Stable below 100 °C; irreversible thermal decomposition above 240 °C, releasing irritating nitrogen-containing heterocyclic fumes
- Chemical Compatibility: Compatible with weak acidic aqueous buffers; incompatible with strong alkalis, strong oxidants, heavy metal ions
3. Main Application Fields
- Core Application: Biochemical Laboratory Research Reagent
Classic thiamine antagonist for cell metabolism, neurobiology and microbial culture research; used to induce vitamin B1 deficiency models - Pharmaceutical Synthetic Intermediate
Raw material for anti-protozoal and anti-parasitic drug screening compounds - Pharmacology Reference Standard
Control substance for HPLC detection of thiamine analog impurities in vitamin formulations - Microbial Culture Additive
Selective inhibitor for thiamine-dependent strains in microbial screening experiments
4. Platform Category & Product Group Selection Guide
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical Intermediates
Reason: It is a bioactive heterocyclic salt for pharmaceutical and biochemical research, classified as pharmaceutical intermediate.
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do not select Basic Organic Chemicals; this product is mainly used for pharmaceutical and biochemical research, matching pharmaceutical chemical grouping.
3. Standard Foreign Trade Packaging Specification
1g/5g glass vial with nitrogen seal for lab samples; 25kg fiber drum lined with double PE inner bags for bulk orders; customized sterile packaging available
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 137-88-2 |
| Molecular Formula | C14H19ClN4 |
| Appearance | Uniform white crystalline powder without yellow discoloration |
| HPLC Purity | Biochemical Grade ≥99.0%, Reference Standard ≥99.8% |
| Water Content (KF Method) | ≤0.40% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Light-proof nitrogen-sealed aluminum foil vacuum bag, low-temperature sealed container |
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