Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Atosiban
1. Basic Product Information
Product Name: Atosiban
CAS Number: 90779-69-4
Molecular Formula: C??H??N??O??S?
Molecular Weight: 994.19
Synonyms: 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithine vasotocin; Tractocile; Oxytocin receptor antagonist peptide
Product Category: Injectable Human Pharmaceutical API, Synthetic Cyclic Peptide Drug Raw Material, Obstetric Pharmaceutical Intermediate, Pharmacology Research Reference Standard
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White to off-white lyophilized crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in purified water, dilute acetic acid and aqueous buffer solutions; soluble in methanol; slightly soluble in anhydrous ethanol; insoluble in acetone, chloroform, hexane and non-polar solvents
- Melting Point: Decomposes above 172 °C without clear melting range
- Optical Rotation: -30° ~ -24° (c=1, 0.1M Acetic Acid, 20°C)
- Hygroscopicity: Highly hygroscopic, rapidly absorbs moisture in ambient air
- Aqueous Stability: Stable under weak acidic pH 4–6; rapid peptide bond hydrolysis and disulfide bond cleavage under alkaline, high-temperature or repeated freeze-thaw conditions
Chemical Characteristics
- Molecular Structure: Cyclic nonapeptide with intramolecular disulfide bond, containing multiple amino, amide, hydroxyl and guanidinium functional groups
- Pharmacological Mechanism: Competitive selective oxytocin receptor antagonist, suppresses uterine smooth muscle contraction to delay preterm labor in obstetric clinical treatment
- Degradation Risk: Disulfide cross-link and peptide backbones break down under heat, strong base or long-term light exposure, leading to loss of biological activity
- Photostability: Extremely light-sensitive; UV irradiation triggers oxidative degradation and visible yellow discoloration
- Thermal Stability: Stable at 2–8 °C; irreversible bioactivity loss occurs above 40 °C
- Chemical Compatibility: Compatible with sterile weak acidic injection buffers; incompatible with alkaline reagents, heavy metal ions, strong oxidants and reducing agents
3. Main Application Fields
- Core Application: Obstetric Injectable Peptide API
Approved active pharmaceutical ingredient for intravenous injection formulations, clinically indicated for inhibition of premature uterine contractions to treat threatened preterm labour in pregnant women - Pharmaceutical Formulation Intermediate
Raw material for sterile lyophilized injection finished products, used in hospital obstetric departments worldwide - Biomedical Pharmacology Research Reagent
Standard oxytocin antagonist for uterine smooth muscle cell, reproductive endocrinology and preterm birth mechanism research - HPLC Certified Reference Standard
Reference substance for related peptide impurity testing of atosiban bulk drug and injection preparations
4. Platform Category & Product Group Selection Guide
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical Intermediates
Reason: Regulated prescription human obstetric peptide API, classified as pharmaceutical intermediate, not veterinary or industrial chemical categories.
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do NOT select Basic Organic Chemicals; this is a regulated human therapeutic peptide raw material, matching pharmaceutical chemical grouping.
3. Standard Foreign Trade Packaging Specification
5mg/10mg/50mg nitrogen-sealed glass vials for laboratory research samples; 1g/5g aluminum foil vacuum bags, 25kg double PE-lined fiber drums for bulk sterile API orders; customized sterile injection-grade packaging is available upon request
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 90779-69-4 |
| Molecular Formula | C??H??N??O??S? |
| Appearance | Uniform white lyophilized powder without yellow or brown discoloration |
| HPLC Purity | Injection API Grade ≥98.5%, Reference Standard ≥99.5% |
| Optical Rotation | -30° ~ -24° (c=1, 0.1M Acetic Acid) |
| Water Content (KF Method) | ≤0.50% |
| Single Unknown Peptide Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Bacterial Endotoxin | ≤0.1 EU/mg (Injection Sterile Grade) |
| Standard Storage Package | Light-proof nitrogen-filled aluminum foil vacuum bag, low-temperature sealed container |
...
Product
