Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2,4-Dichloropyrimidine
1. Basic Product Information
Product Name: 2,4-Dichloropyrimidine
CAS Number: 3934-20-1
Molecular Formula: C4H2Cl2N2
Molecular Weight: 148.98
Synonyms: 2,4-Dichloro-1,3-pyrimidine
Product Category: Heterocyclic pharmaceutical intermediate, pesticide intermediate, fine chemical synthetic raw material
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White to off-white crystalline powder
- Odor: Slight characteristic heterocyclic odor
- Solubility: Soluble in dichloromethane, chloroform, ethyl acetate, toluene and methanol; slightly soluble in ethanol; insoluble in water and aliphatic alkanes
- Melting Point: 58–62 °C
- Boiling Point: 246 °C (760 mmHg)
- Density (20 °C): 1.47 g/cm3
- Hygroscopicity: Non-hygroscopic under sealed dry storage
- Aqueous Stability: Stable under neutral and weakly acidic conditions; undergoes hydrolysis under heated alkaline aqueous solution to produce pyrimidinol derivatives
Chemical Characteristics
- Molecular Structure: Pyrimidine heterocycle substituted with two chlorine atoms at C2 and C4 positions
- Core Functional Mechanism: The two chlorine atoms have high reactivity for nucleophilic substitution reactions; easily reacts with amines, alcohols, phenols and thiols to construct pyrimidine-based drug and pesticide skeletons
- Photostability: Slightly light-sensitive; long-term ultraviolet irradiation leads to trace dechlorination impurities
- Thermal Stability: Stable below 50 °C; above melting point, slow sublimation occurs; high-temperature decomposition releases toxic hydrogen chloride and nitrogen-containing fumes
- Chemical Compatibility: Compatible with anhydrous aprotic solvents; incompatible with strong alkaline solutions, strong nucleophiles and strong oxidants
3. Main Application Fields
- Core Application: Pharmaceutical Intermediate
Key building block for synthesizing anti-tumor drugs, anti-viral medicines, JAK inhibitors and kinase-targeted small molecule pharmaceuticals via nucleophilic substitution at C2/C4 sites - Agrochemical Intermediate
Raw material for manufacturing herbicides, fungicides and insecticides with pyrimidine parent ring structure - Organic Synthetic Reagent
Model substrate for heterocyclic synthesis and nucleophilic substitution reaction research in laboratory fine chemistry
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical Intermediates
Reason: Active dichloropyrimidine heterocyclic raw material dedicated to pharmaceutical and pesticide synthesis
2) English Product Group Dropdown Options
Recommended Selection: Basic Organic Chemicals
Do NOT select Pharmaceutical Chemicals exclusively; it is an intermediate rather than finished drug API
3. Standard Foreign Trade Packaging Specification
1kg aluminum foil vacuum bag for lab synthesis tests; 25kg double PE-lined light-proof fiber drum for bulk factory orders
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 3934-20-1 |
| Molecular Formula | C4H2Cl2N2 |
| Appearance | Uniform white crystalline powder without dark impurities |
| HPLC Purity | Pharma Grade ≥99.0%, Synthetic Grade ≥98.5% |
| Melting Point | 58–62 °C |
| Water Content (KF Method) | ≤0.20% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Lightproof nitrogen-sealed aluminum foil vacuum bag, dry warehouse storage |
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