Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
5-Fluorocytosine
1. Basic Product Information
Product Name: 5-Fluorocytosine
Short Name: 5-FC
CAS Number: 2022-85-7
Molecular Formula: C4H4FN3O
Molecular Weight: 129.09
Synonyms: Flucytosine, 4-Amino-5-fluoro-2(1H)-pyrimidinone, NSC 103805, Ro 2-9915
Product Category: Human antifungal API, pyrimidine heterocyclic intermediate, biochemical research reagent, nucleic acid analog substrate
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in water (12 g/L at 25°C); soluble in hot ethanol, methanol; sparingly soluble in cold alcohols; insoluble in ether, benzene, alkanes and chloroform
- Melting Point: 295–297 °C (decomposes)
- Density (20 °C): 1.56 g/cm3
- Hygroscopicity: Slightly hygroscopic under high humidity air
- Aqueous Stability: Stable under neutral and weakly acidic aqueous environments; slow hydrolysis occurs under prolonged heating with strong alkali
Chemical Characteristics
- Molecular Structure: Pyrimidine heterocyclic base analog with fluorine substitution at C5 position, containing amino and carbonyl groups on pyrimidine ring
- Core Functional Mechanism: Antifungal nucleoside analog; converted into fluorinated nucleotides inside fungal cells to block DNA/RNA synthesis and inhibit fungal proliferation; displays mild cytotoxicity toward mammalian cells at high doses
- Photostability: Light-sensitive; long-term UV exposure triggers slight discoloration and reduces biological activity
- Thermal Stability: Stable below 250 °C; thermal decomposition above melting point releases irritant fluorine-containing and nitrogen volatile fumes
- Chemical Compatibility: Compatible with neutral biological buffers and polar protic solvents; incompatible with strong oxidants, concentrated strong alkalis and heavy metal ions
3. Main Application Fields
- Core Application: Human Antifungal Pharmaceutical API
Main raw material for oral and injectable antifungal formulations, clinically applied to treat systemic infections caused by Candida, Cryptococcus neoformans including meningitis, sepsis, urinary and respiratory fungal infections; often combined with amphotericin B for synergistic therapy - Biochemical & Molecular Biology Research Reagent
Nucleic acid metabolism inhibitor for cell culture, fungal resistance mechanism research, tumor cell proliferation inhibition assays and microbial screening experiments - Heterocyclic Synthetic Intermediate
Fluoropyrimidine building block for developing novel antifungal, antitumor and antiviral small-molecule compounds - Microbiological Culture Additive
Selective additive in fungal culture medium to suppress non-target bacterial growth
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical Intermediates
Reason: Special fluoropyrimidine human antifungal bulk drug and fine heterocyclic synthetic raw material
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do NOT categorize as general industrial chemicals; it is prescription human-use antifungal API
3. Standard Foreign Trade Packaging Specification
1g/5g nitrogen-sealed glass vials for lab research tests; 1kg aluminum foil vacuum bags for pharmaceutical pilot synthesis; 25kg double PE-lined light-proof fiber drums for GMP bulk production
5. Quality Specification Table
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