Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-Amino-5-chlorobenzophenone
1. Basic Product Information
Product Name: 2-Amino-5-chlorobenzophenone
CAS Number: 719-59-5
Molecular Formula: C13H10ClNO
Molecular Weight: 231.68
Synonyms: (2-Amino-5-chlorophenyl)phenylmethanone, 5-Chloro-2-aminobenzophenone
Product Category: Benzodiazepine pharmaceutical intermediate, fine aromatic synthetic raw material, organic synthesis building block
2. Physical and Chemical Properties
Physical Indicators
- Appearance: Pale yellow to off-white crystalline powder
- Odor: Mild aromatic odor
- Solubility: Soluble in ethanol, methanol, chloroform, ethyl acetate and toluene; slightly soluble in hot water; insoluble in cold water and aliphatic hydrocarbons
- Melting Point: 98–102 °C
- Density (20 °C): 1.27 g/cm3
- Hygroscopicity: Non-hygroscopic under sealed dry storage
- Aqueous Stability: Stable under neutral and weakly acidic conditions; prone to oxidation and darkening under strong alkaline heating or prolonged air exposure
Chemical Characteristics
- Molecular Structure: Diphenyl ketone skeleton with amino group at ortho position and chlorine substituent at para position of the amino benzene ring
- Core Functional Mechanism: Key starting material for cyclization reaction to synthesize benzodiazepine ring system; amino and carbonyl groups support condensation, cyclization and halogen substitution reactions
- Photostability: Light-sensitive; long-term UV irradiation generates dark oxidative impurities
- Thermal Stability: Stable below 80 °C; high-temperature decomposition releases irritating chlorine-containing aromatic fumes
- Chemical Compatibility: Compatible with anhydrous polar and non-polar organic solvents; incompatible with strong oxidants, concentrated strong alkalis and heavy metal salts
3. Main Application Fields
- Core Application: Benzodiazepine Drug Intermediate
Critical raw material for synthesizing clonazepam, lorazepam, nitrazepam and other sedative, anxiolytic and anticonvulsant benzodiazepine APIs - Fine Chemical Synthetic Intermediate
Precursor for manufacturing fluorescent dyes, organic pigments and aromatic amine derivatives - Laboratory Organic Synthesis Reagent
Aromatic amino ketone substrate for cyclization, reduction and nucleophilic substitution reaction research
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical Intermediates
Reason: Core aromatic intermediate for benzodiazepine psychoactive drug synthesis
2) English Product Group Dropdown Options
Recommended Selection: Basic Organic Chemicals
Do NOT solely categorize as finished pharmaceutical chemicals; it is a synthetic intermediate rather than finished API
3. Standard Foreign Trade Packaging Specification
1kg aluminum foil vacuum bag for lab synthesis trials; 25kg double PE-lined light-proof fiber drum for pharmaceutical mass production
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 719-59-5 |
| Molecular Formula | C13H10ClNO |
| Appearance | Uniform pale white crystalline powder without dark brown impurities |
| HPLC Purity | Pharma Grade ≥99.0%, Synthetic Grade ≥98.5% |
| Melting Point | 98–102 °C |
| Water Content (KF Method) | ≤0.20% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Lightproof nitrogen-sealed vacuum aluminum foil bag, dry warehouse storage |
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