Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Terbinafine Hydrochloride
1. Basic Product Information
Product Name: Terbinafine Hydrochloride
CAS Number: 78628-80-5
Molecular Formula: C21H26ClN·HCl
Molecular Weight: 327.90
Synonyms: (E)-N-(6,6-Dimethylhept-2-en-4-ynyl)-N-methylnaphthalen-1-methylamine hydrochloride
Product Category: Human antifungal API, allylamine antifungal intermediate, dermatological pharmaceutical raw material
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Soluble in methanol, ethanol, isopropanol; slightly soluble in water; insoluble in ether, alkanes and benzene
- Melting Point: 204–208 °C (decomposes)
- Specific Rotation: Racemic mixture, no optical rotation
- Density (20 °C): 1.09 g/cm3
- Hygroscopicity: Slightly hygroscopic under high humidity
- Aqueous Stability: Stable under neutral and weakly acidic conditions; hydrolytic degradation occurs under strong alkaline heating
Chemical Characteristics
- Molecular Structure: Allylamine naphthalene derivative combined with hydrochloride salt, containing alkynyl and olefin functional groups
- Core Functional Mechanism: Squalene epoxidase inhibitor; blocks fungal cell membrane synthesis, broad-spectrum fungicidal against dermatophytes, molds and yeasts for skin, nail and hair fungal infections
- Photostability: Light-sensitive; UV exposure causes yellow discoloration and reduced potency
- Thermal Stability: Stable below 180 °C; thermal decomposition releases irritant amine and chlorinated volatile fumes
- Chemical Compatibility: Compatible with polar protic solvents and pharmaceutical excipients; incompatible with strong oxidants, concentrated alkalis and heavy metal salts
3. Main Application Fields
- Core Application: Oral & Topical Antifungal API
Key raw material for antifungal creams, sprays, oral tablets for treating tinea pedis, tinea corporis, onychomycosis and cutaneous candidiasis - Dermatological Formulation Intermediate
Active ingredient for dermatological compound preparations combined with anti-inflammatory additives - Biochemical Research Reagent
Inhibitor for fungal cell membrane metabolism research in microbiology laboratories
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical Intermediates
Reason: Finished human-use antifungal API for dermatological clinical drugs
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do NOT classify as general industrial chemicals; it is clinical prescription antifungal active pharmaceutical ingredient
3. Standard Foreign Trade Packaging Specification
1g / 5g nitrogen-sealed amber glass vials for reference standards; 1kg aluminum foil vacuum bags for pharmaceutical pilot production; 25kg double PE-lined lightproof fiber drums for GMP bulk batches
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 78628-80-5 |
| Molecular Formula | C21H26ClN·HCl |
| Appearance | Uniform white crystalline powder without yellow impurities |
| HPLC Purity | Pharma Grade ≥99.0%, Reference Standard ≥99.8% |
| Melting Point | 204–208 °C (decomposes) |
| Water Content (KF Method) | ≤0.30% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Lightproof nitrogen-filled vacuum aluminum foil bag, cool dry warehouse storage |
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