Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Chlorpheniramine Maleate
1. Basic Product Information
Product Name: Chlorpheniramine Maleate
CAS Number: 113-92-8
Molecular Formula: C16H19ClN2·C4H4O4
Molecular Weight: 390.87
Synonyms: Chlorphenamine Maleate, 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine maleate
Product Category: Human antihistamine API, anti-allergy pharmaceutical raw material, cold medicine active ingredient
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White crystalline powder
- Odor: Odorless, slight bitter taste
- Solubility: Freely soluble in water, methanol and ethanol; slightly soluble in acetone; insoluble in ether, benzene and aliphatic hydrocarbons
- Melting Point: 130–135 °C
- Optical Activity: Racemic mixture without optical rotation
- Density (20 °C): 1.22 g/cm3
- Hygroscopicity: Slightly hygroscopic under high humidity environment
- Aqueous Stability: Stable under neutral and weakly acidic aqueous solutions; slow degradation occurs under high temperature and strong alkaline conditions
Chemical Characteristics
- Molecular Structure: Pyridine alkylamine antihistamine combined with maleic acid salt, containing chloro-substituted benzene ring and dimethylamino alkyl side chain
- Core Functional Mechanism: Competitive H1 histamine receptor antagonist; relieves allergic symptoms including rhinitis, urticaria, pruritus; widely used in compound cold and flu preparations
- Photostability: Light-sensitive; long-term UV irradiation triggers yellow discoloration and reduces pharmacological activity
- Thermal Stability: Stable below 100 °C; thermal decomposition above melting point releases irritant chlorine and nitrogen-containing volatile fumes
- Chemical Compatibility: Compatible with most pharmaceutical excipients and polar protic solvents; incompatible with strong oxidants, concentrated strong alkalis and heavy metal salts
3. Main Application Fields
- Core Application: Oral Antihistamine API
Main active raw material for anti-allergy tablets, syrups, capsules and compound cold preparations, clinically used for allergic rhinitis, skin allergies and cold-related runny nose - Pharmaceutical Compound Preparation Auxiliary
Combined with paracetamol, pseudoephedrine and dextromethorphan to produce multi-component cold relief drugs - Biochemical Research Reagent
H1 receptor antagonist standard for immunology and allergy mechanism research in laboratory
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical APIs
Reason: Finished human antihistamine active pharmaceutical ingredient for over-the-counter cold and allergy medicines
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do NOT classify as general industrial chemicals; it is clinical human-use anti-allergy API
3. Standard Foreign Trade Packaging Specification
1g / 5g amber glass vials sealed with nitrogen for reference standards; 1kg aluminum foil vacuum bags for pharmaceutical pilot batches; 25kg double PE-lined light-proof fiber drums for GMP mass production
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 113-92-8 |
| Molecular Formula | C16H19ClN2·C4H4O4 |
| Appearance | Uniform white crystalline powder without yellow impurities |
| HPLC Purity | Pharma Grade ≥99.0%, Reference Standard ≥99.8% |
| Melting Point | 130–135 °C |
| Water Content (KF Method) | ≤0.30% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Lightproof nitrogen-sealed vacuum aluminum foil bag, cool dry warehouse storage |
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