Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Tetracaine Hydrochloride
1. Basic Product Information
Product Name: Tetracaine Hydrochloride
CAS Number: 136-47-0
Molecular Formula: C15H24N2O2·HCl
Molecular Weight: 300.83
Synonyms: Amethocaine Hydrochloride, 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
Product Category: Human clinical local anesthetic API, ophthalmic pharmaceutical raw material, ester-type anesthetic salt intermediate
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White crystalline powder
- Odor: Odorless, characteristic bitter taste
- Solubility: Freely soluble in water, methanol and ethanol; slightly soluble in acetone; insoluble in ethyl ether, benzene and aliphatic hydrocarbons
- Melting Point: 147–151 °C
- Optical Property: Racemic compound without specific rotation
- Density (20 °C): 1.08 g/cm3
- Hygroscopicity: Slightly hygroscopic under high humidity ambient air
- Aqueous Stability: Stable in neutral and weakly acidic aqueous solutions; ester hydrolysis will occur upon long-time heating under strong alkaline conditions, generating related benzoic acid impurities
Chemical Characteristics
- Molecular Structure: Hydrochloride salt of tetracaine base, para-aminobenzoate ester structure containing butylamino group and dimethylaminoethyl ester side chain
- Core Functional Mechanism: Long-acting ester local anesthetic; blocks sodium ion channels on nerve cell membrane to inhibit nerve impulse transmission; widely used for ocular, nasal and mucosal surface anesthesia
- Photostability: Light-sensitive; prolonged UV irradiation causes yellow discoloration and reduces anesthetic efficacy
- Thermal Stability: Stable below 120 °C; high-temperature heating accelerates ester bond hydrolysis decomposition
- Chemical Compatibility: Compatible with polar protic solvents and common pharmaceutical excipients; incompatible with strong oxidants, concentrated strong alkalis and heavy metal ions
3. Main Application Fields
- Core Application: Clinical Local Anesthetic API
Key active raw material for ophthalmic eye drops, nasal mucosal sprays and topical surface anesthetic preparations; used for surface anesthesia in ophthalmology, otolaryngology and dermatology - Compound Pharmaceutical Preparation Raw Material
Formulation component for compound anesthetic syrups and topical pain-relief creams - Biochemical Laboratory Reagent
Standard inhibitor for nerve sodium channel research in neuroscience and pharmacology experiments
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical APIs
Reason: Finished prescription human-use local anesthetic hydrochloride API
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do NOT classify as general industrial chemicals; it is regulated clinical anesthetic active pharmaceutical ingredient
3. Standard Foreign Trade Packaging Specification
1g / 5g nitrogen-filled amber glass vials for reference standards; 1kg aluminum foil vacuum bags for pharmaceutical pilot batches; 25kg double PE-lined light-proof fiber drums for GMP mass production
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 136-47-0 |
| Molecular Formula | C15H24N2O2·HCl |
| Appearance | Uniform white crystalline powder without yellow discoloration impurities |
| HPLC Purity | Pharma Grade ≥99.0%, Reference Standard ≥99.8% |
| Melting Point | 147–151 °C |
| Water Content (KF Method) | ≤0.30% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Lightproof nitrogen-sealed vacuum aluminum foil bag, cool dry warehouse storage |
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