Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
D-Biotin
1. Basic Product Information
Product Name: D-Biotin
Synonyms: Vitamin H, Vitamin B7, cis-Tetrahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid
CAS Number: 58-85-5
Molecular Formula: C10H16N2O3S
Molecular Weight: 244.31
Product Category: Biochemical raw material, food & feed vitamin fortifier, cell culture additive, pharmaceutical API & excipient, cosmetic active ingredient
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White crystalline powder
- Odor: Odorless, faint mild sour taste
- Solubility: Slightly soluble in cold water and ethanol; soluble in hot water, hot alcohol; insoluble in chloroform, ether, benzene and aliphatic hydrocarbons
- Melting Point: 232–233 °C (decomposes)
- Specific Rotation [α]D2?: +89° ~ +93° (c=1, 0.1M NaOH)
- Density (20 °C): 1.41 g/cm3
- Hygroscopicity: Slightly hygroscopic under high humidity air
- Aqueous Stability: Stable under neutral and weakly acidic aqueous solutions; prone to oxidation and discoloration under strong alkaline heating or long-term UV irradiation
Chemical Characteristics
- Molecular Structure: Fused thiophene-imidazole heterocyclic ring with pentanoic acid side chain, chiral natural D-form vitamin
- Core Functional Mechanism: Essential coenzyme for human fatty acid synthesis, gluconeogenesis and amino acid metabolism; acts as carboxyl carrier in intracellular enzymatic reactions
- Photostability: Light-sensitive; long-term UV exposure generates dark oxidative impurities and reduces biological activity
- Thermal Stability: Stable below 200 °C; thermal decomposition above melting point releases irritating sulfur and nitrogen-containing volatile fumes
- Chemical Compatibility: Compatible with polar protic solvents and most pharmaceutical excipients; incompatible with strong oxidants, concentrated strong alkalis and heavy metal ions
3. Main Application Fields
- Core Application: Food & Feed Nutritional Supplement
Vitamin additive for dairy, beverage, compound vitamin tablets, infant formula and animal feed; prevents biotin deficiency leading to hair loss, dermatitis and growth retardation - Cell & Tissue Culture Reagent
Key medium component for mammalian cell culture, antibody expression and microbial fermentation to support cell proliferation - Pharmaceutical Raw Material
Raw material for multi-vitamin oral preparations, hair care anti-hair loss compound drugs and dermatological formulations - Cosmetic Functional Raw Material
Hair-nourishing, anti-breakage and scalp conditioning additive in shampoo, hair serum and anti-aging skincare products - Biochemical Laboratory Standard
Coenzyme reference standard for enzyme metabolism and biotin labeling experiment research
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Biochemical Reagents
Reason: GMP-grade sulfur-containing heterocyclic vitamin raw material for nutrition, biotech and pharmaceutical industries
2) English Product Group Dropdown Options
Recommended Selection: Basic Organic Chemicals
Do NOT solely classify as pharmaceutical chemicals; it is multi-purpose food-grade biochemical vitamin
3. Standard Foreign Trade Packaging Specification
1g / 5g nitrogen-sealed amber glass vials for reference standards; 1kg aluminum foil vacuum bags for biotech pilot batches; 25kg double PE-lined lightproof fiber drums for bulk food/pharma grade production
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 58-85-5 |
| Molecular Formula | C10H16N2O3S |
| Appearance | Uniform white crystalline powder without yellow/brown impurities |
| HPLC Purity | Pharma Grade ≥99.0%, Reference Standard ≥99.8% |
| Melting Point | 232–233 °C (decomposes) |
| Specific Rotation | +89° ~ +93° |
| Water Content (KF Method) | ≤0.30% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Lightproof nitrogen-filled vacuum aluminum foil bag, cool dry warehouse storage |
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