Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Tretinoin
1. Basic Product Information
Product Name: Tretinoin
Synonyms: All-trans-Retinoic acid, Vitamin A acid, Retinoic acid
CAS Number: 302-79-4
Molecular Formula: C20H28O2
Molecular Weight: 300.44
Product Category: Human dermatological pharmaceutical API, retinoid anti-tumor intermediate, cosmetic active raw material, cell differentiation biochemical reagent
2. Physical and Chemical Properties
Physical Indicators
- Appearance: Yellow to pale orange crystalline powder
- Odor: Odorless
- Solubility: Soluble in chloroform, dimethyl sulfoxide, hot ethanol; sparingly soluble in cold ethanol; insoluble in water and aliphatic hydrocarbons
- Melting Point: 180–182 °C (decomposes)
- Optical Activity: No chiral carbon, no optical rotation
- Density (20 °C): 1.05 g/cm3
- Hygroscopicity: Non-hygroscopic under sealed dry storage
- Aqueous Stability: Unstable in aqueous medium; prone to isomerization and oxidation under light, heat or alkaline conditions
Chemical Characteristics
- Molecular Structure: Polyene carboxylic acid retinoid with four conjugated double bonds on long aliphatic side chain linked to cyclohexenyl ring
- Core Functional Mechanism: Retinoid nuclear receptor agonist; regulates epidermal cell proliferation and differentiation; accelerates keratin metabolism for acne treatment; also used for acute promyelocytic leukemia induction therapy; strong teratogenic risk to fetus
- Photostability: Extremely light-sensitive; visible light and UV radiation trigger cis-isomerization and oxidative degradation, fading active potency
- Thermal Stability: Stable below 60 °C; heating above 90 °C accelerates double bond isomerization and decomposition
- Chemical Compatibility: Compatible with anhydrous non-protic solvents and oil-based pharmaceutical excipients; incompatible with strong oxidants, concentrated strong alkalis and heavy metal salts
3. Main Application Fields
- Core Application: Dermatological Prescription API
Active raw material for anti-acne creams, gels and anti-photoaging topical preparations; clinically used for acne vulgaris, hyperpigmentation and keratosis disorders - Anti-Tumor Pharmaceutical Raw Material
Key API for oral and injectable formulations to treat acute promyelocytic leukemia (APL) - Biochemical Research Reagent
Cell differentiation inducer standard for oncology, dermatology and stem cell laboratory research - High-End Cosmetic Active Ingredient
Anti-aging, exfoliating and brightening additive in professional skincare products (strict dosage control required)
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical APIs
Reason: Clinical prescription retinoid pharmaceutical active ingredient with teratogenic risk control requirements
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do NOT classify as general industrial chemicals; it is regulated human prescription pharmaceutical API
3. Standard Foreign Trade Packaging Specification
1g nitrogen-sealed amber glass vial for reference standard; 1kg vacuum aluminum foil bag for pharmaceutical pilot batches; 25kg double PE-lined fully lightproof fiber drum for GMP bulk production
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 302-79-4 |
| Molecular Formula | C20H28O2 |
| Appearance | Uniform bright yellow crystalline powder without brown black impurities |
| HPLC All-trans Tretinoin | Pharma Grade ≥99.0%, Reference Standard ≥99.8% |
| Water Content (KF Method) | ≤0.20% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Isomers & Impurities | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Lightproof nitrogen-filled vacuum aluminum foil bag, low-temperature dark warehouse storage |
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