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Glycerophosphoinositol 4,5-bisphosphate
1. Basic Product Information
Product Name: Glycerophosphoinositol 4,5-bisphosphate
CAS Number: 94161-15-6
Molecular Formula: C9H21O17P3
Molecular Weight: 494.17
Synonyms: GroPI(4,5)P2, GPIP2, myo-Inositol,4,5-bis(dihydrogen phosphate) 1-(2,3-dihydroxypropyl hydrogen phosphate)
Product Category: Biochemical signal transduction substrate, cell biology research reagent, phosphoinositide standard, enzyme research substrate, lipid signaling experimental raw material
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White off-white amorphous powder
- Odor: Odorless
- Solubility: Freely soluble in water; slightly soluble in methanol; insoluble in ethanol, chloroform, ether and aliphatic hydrocarbon solvents
- Melting Point: Decomposes gradually above 120 °C without fixed melting point
- Density (20 °C): 1.52 g/cm3
- Hygroscopicity: Strongly hygroscopic under high humidity air
- Aqueous Stability: Unstable in aqueous solution; easy to dephosphorylate and isomerize under UV irradiation, high temperature or alkaline environment
Chemical Characteristics
- Molecular Structure: Glycerol-inositol fused trisphosphate heterocyclic compound, glycerol backbone linked to myo-inositol ring via phosphate ester bonds, with two additional phosphate groups at C4 and C5 positions of inositol ring
- Core Functional Mechanism: Water-soluble phosphoinositide analog without fatty acid chains; intracellular calcium signal regulation substrate, slow degradation analog of IP3; specifically binds PH domain protein to regulate cytoskeleton, ion channel and membrane transport functions
- Photostability: Extremely light-sensitive; UV and visible light trigger phosphate group shedding and ring isomerization, reducing biological activity
- Thermal Stability: Stable below 60 °C; heating above 90 °C accelerates dephosphorylation decomposition to generate free phosphate and inositol fragments
- Chemical Compatibility: Compatible with neutral biological buffer, water-based cell culture medium; incompatible with strong oxidants, concentrated strong alkalis and heavy metal ions
3. Main Application Fields
- Core Application: Molecular Biology Signal Research Reagent
Standard substrate for intracellular calcium signal transduction, PLC enzyme and PI3K kinase activity detection experiments - Cell Culture Biochemical Additive
Medium supplement for eukaryotic cell culture to study cell migration, cytoskeleton rearrangement and tumor cell invasion mechanism - Drug Screening Tool Compound
Positive control compound for screening phosphoinositide-targeted anti-tumor and anti-inflammatory small molecule inhibitors - Biochemistry Reference Standard
HPLC chromatographic reference substance for quantitative detection of intracellular polyphosphoinositide content - Neurobiology Research Raw Material
Experimental reagent for neuronal ion channel regulation and nerve cell signal transmission research
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Biochemical Research Reagents
Reason: Water-soluble polyphosphoinositide biochemical standard exclusively for molecular biology and cell signal research
2) English Product Group Dropdown Options
Recommended Selection: Biochemical Reagents
Do NOT classify as industrial daily chemical raw materials; it is laboratory-grade biological research special reagent
3. Standard Foreign Trade Packaging Specification
10mg / 50mg nitrogen-sealed amber glass vial for reference standard; 1g vacuum aluminum foil bag for laboratory batch use; lightproof low-temperature sealed packaging for bulk small batches
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 94161-15-6 |
| Molecular Formula | C9H21O17P3 |
| Appearance | Uniform white amorphous powder without yellow brown degradation impurities |
| HPLC Purity | Research Grade ≥99.0%, Reference Standard ≥99.8% |
| Water Content (KF Method) | ≤0.30% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Phosphate Degradants | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Standard Storage Package | Lightproof nitrogen-filled vacuum aluminum foil bag, -20 ℃ cold dark warehouse storage |
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